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KMID : 0370220060500050322
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Yakhak Hoeji
2006 Volume.50 No. 5 p.322 ~ p.325
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Synthesis of 6-Hydroxy-7-methoxychroman-2-carboxylic Acid Dialkylaminoalkylamides
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Kwak Jae-Hwan
Lee Keum-Ho
Jung Jae-Kyeong
Cho Jung-Sook
Lee Hee-soon
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Abstract
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In the course of developing novel antioxidants, we synthesized four of 6-hydroxy-7-methoxy-4-oxochroman-2-carboxylic acid dialkylamides (3a-d) (13~18%) and four of 6-hydroxy-7-methoxychroman-2-carboxylic acid dialkylamides (4a-d) (52~89%), incorporating the basic amine functionality. None of these compounds exhibited significant antioxidant activity possibly due to the hydrophilic character of the basic amine side chains.
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KEYWORD
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antioxidants, 4-oxochroman, chroman-2-carboxylic acid
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